Beta Carotene:
In
the last few years increasing numbers of reports have suggested
that the use of Beta Carotene may act to prevent the development
of various malignancies. Beta Carotene and other similar compounds
have differentiating properties that appear to affect cell growth
and maturation. Beta Carotene is not toxic to the liver even in
high doses in contrast to Vitamin A. Large doses of Beta Carotene
will increase the body's demands for Vitamin E; therefore, those
of you on 50,000 to 100,000 units of beta carotene per day will
need to also increase your vitamin E to 1,000 to 2,000 units per
day. The definitive role of beta carotene/vitamin E is yet to
be understood, but there is sufficient reason to use beta carotene
in a dose of 50,000 units per day. There is no need to supplement
this with carrot juice or vitamin A. Beta carotene, like vitamin
A and E is stored in the liver. Current clinical trials in prevention
of cervix cancer and cancer of the lung and breast are using beta
carotene. This may also be helpful in the prevention of colon
cancer and melanoma.
VITAMIN E:
Please
read the above. Vitamin E is an important anti-oxidant. It acts
as a free radical scavenger to prevent the byproducts of chemical-cell
interaction to cause cell damage. Free radicals are likely responsible
for all or most of the degenerative diseases e.g. arthritis, heart
disease, cancer, senility etc. The absorption or scavenging of
free radicals would protect our cells from this type of injury.
Other free radical scavengers include zinc, vitamin C, and selenium.
Studies have reported vitamin E to protect against some of the
toxicities of ionizing radiation. Vitamin E may help to decrease
the toxicity of certain chemotherapy drugs. Adriamycin is an important
anti-cancer drug with potential major toxicity to the heart. The
use of 1000 to 2,000 units of vitamin E per day may help to decrease
this toxicity. Vitamin E may decrease some of the harmful effects
of solar radiation on the skin. As cited above it works well in
conjunction with beta carotene. Vitamin E appears to have stabilizing
effect on the vascular system and is useful in decreasing menopausal
and premenstrual symptoms. It is useful in decreasing leg cramps
occurring especially at night. Vitamin E can be used in lotions
or creams to protect the skin or to treat for burns. It is also
helpful to treat burns secondary to radiation therapy. I have
also used it with good results in patients with dermatitis resulting
from poor blood circulation i.e. stasis dermatitis. It is commonly
prescribed for topical use in pregnant women to prevent stretch
marks on the abdomen. More recently it has been used to prevent
or treat mucositis resulting from chemotherapy. I advise patients
to bite into a 1000 unit capsule and swish the vitamin E around
the mouth and over the mucous membranes lining the cheeks. This
is done three to four times a day. You can also use liquid vitamin
E to do this.
B COMPLEX:
The B complexes
are important membrane stabilizers. They are natural tranquilizers
or anti-stress vitamins because of this property. They are important
vitamins to help nerve function. The B complex vitamins contain
PABA which is important in protecting the skin against the harmful
effects of Ultra-violet radiation. PABA is an excellent UV screening
agent and helps to protect against the development of skin cancer
or sun-induced skin damage e.g. wrinkling and solar keratoses.
Fair complexioned people should avoid sun exposure and should
use sun- blockers with at least a 15 factor as well as use B complex
orally. Such people are actinic or sun sensitive and are at a
greater risk for the development of skin cancers of all types.
People with red hair, blue or green eyes tend to be sun sensitive
(actinic sensitive). Women using oral contraceptives increase
their utilization of the B vitamins and need to supplement their
diet with B complex. Patient under high stress should do the same.
The B vitamins are water soluble. They are not stored in the body
as are beta carotene and vitamin E. B complex must be taken with
food already in the stomach. If taken on an empty stomach, pain
and nausea are not uncommon. The use of B complex in a dose of
100 mg once to three times a day with meals is recommended per
patient tolerance. If the B complex is being absorbed the urine
will be bright yellow and have a pungent smell due to the
riboflavonoids
present. This is to be expected and should not cause alarm. If
no change in urine color is noted then suspect that your brand
of B complex is not being absorbed by your body- change brands.
VITAMIN C:
This vitamin
is important for tissue healing. Patients with peptic ulcers will
heal faster on vitamin C than those without extra vitamin C. As
mentioned previously, vitamin C is an anti-oxidant. It is also
water soluble as B complex. I advise that it be used in doses
of 2,000 to 6,000 mg after each meal to take advantage of its
anti-oxidant effects. I would start with 1,000 mg after each meal
and increase slowly up to 6,000 mg after each meal. Side-effects
of large doses include diarrhea and flatulence. Studies in Canada
show a decrease number of colon polyps in patients taking high
doses of vitamin C. Such polyps are precursors for colon cancer.
If we can decrease polyp formation with vitamin C perhaps we can
decrease colon cancer as well. The use of vitamin C in this capacity
should accompany a very low fat diet that is high in dietary fiber.
Smoking and alcohol consumption will increase the excretion of
vitamin C. Alcohol will actually deplete all of the water soluble
vitamins. Vitamin C has been touted by Pauling and Cameron to
decrease cancer growth and cause remissions in cancer patients.
I have not seen any evidence in all of the studies published to
warrant that conclusion. The studies published by Pauling and
Cameron were scientifically unsound and poorly controlled. Major
trials using high dose I.V. vitamin C fail to confirm any anti-
cancer effect of this vitamin in patients with established cancer.
High dose vitamin C may be a problem in patients with a tendency
to kidney stone formation. Check with your physician if this is
your situation.
In patients receiving iron supplements to help treat iron deficiency,
the use of vitamin C taken at the same time as the iron medicine
will greatly enhance the absorption of iron. Vitamin C will help
with wound healing and healing of burns. It improves the strength
of the walls of the blood vessels and may help decrease the easy
bruising seen with some patients. Vitamin C in topical form to
prevent sunburn and to absorb the ultraviolet rays will soon be
available.
Vitamin C may help people with low back pain and arthritis due
to its anti- oxidant effects. This and other vitamins need to
be taken over long periods of time. These substances work over
time -- be patient.
SELENIUM: This
is
an anti-oxidant with activity as a free radical scavenger. Populations
with high blood selenium levels are found to have lower death
rates due to cancer. Mormons have high selenium blood levels perhaps
related to their diet. Cancer patients have low selenium blood
levels. Selenium works in harmony with vitamin E. Selenium toxicity
can occur and the dose of selenium should be close to 100 MICROGRAMS
(not milligrams) per day.
CALCIUM-MAGNESIUM:
Calcium is deficient in most of our diets. This deficiency
is
most prevalent in women who have had children and have never
supplemented
their own diets with calcium. Calcium consumption along with exercise
is the best means to prevent calcium deficiency. Once calcium
is lost and signs of osteopenia develop the medical problem may
be hard to reverse. Collapse of bone and fractures commonly of
the pelvis may occur in such individuals. When people "shrink"
with age it is due to vertebral compression fractures caused by
osteopenia, commonly referred to as osteoporosis. Bone density
studies will detect patients having osteopenia. Calcium, like
B complex acts as a membrane stabilizer and natural tranquilizer
as does magnesium and potassium. Calcium and magnesium should
be taken together in a ratio of 2:1. A daily intake of Calcium
of 1,000 to 1,500 mg is reasonable. Calcium/magnesium may be taken
at bedtime to promote sleep. Magnesium in the form of magnesium
oxide in combination with vitamin B-6 has been shown to dissolve
certain types of kidney stones (calcium oxalate stones). This
preparation is called Beelith and is taken twice a day. It is
also helpful in patients with chronic constipation since magnesium
salts act as cathartics. During pregnancy the intake of calcium
and magnesium should be increased to prevent deficiency in mother
and child. Patients with potassium deficiency should always be
checked for magnesium deficiency. In the presence of magnesium
depletion, it is very difficult to replete potassium stores. I
have used a calcium citrate source containing vitamin D to enhance
calcium absorption. This is an effervescent formulation and it
is taken as two tablets dissolved in a glass of cold water per
day. Calcium citrate is better absorbed and utilized than calcium
carbonate. The use of fluoride in a liquid formulation (potassium
fluoride 180 mg/cc) help bind calcium in the bones. Fluoride drops
are taken as 1 drop in juice or water three times per day. This
is a prescription item and must be made up by the pharmacist.
The dose can be slowly increased per the physician. Fluoride in
this concentration can irritate the gastric lining. Slow increases
in dose are important to prevent this side-effect.
ZINC: This
element
is important in wound healing. It also functions as an anti- oxidant.
It is helpful in the treatment of acne. It hastens healing of
peptic ulcer disease and burns. The recommended dose is 100 mg
per day. Chelated zinc will not cause the gastrointestinal distress
the inorganic zinc will. Therefore, request a chelated zinc rather
than zinc sulfate.